0704-883-0675     |      dataprojectng@gmail.com

SOME NEUROPHARMACOLOGICAL PROPERTIES OF METHANOLIC STEM BARK EXTRACT OF FICUS INGENS (MIQUEL) MIQUEL IN MICE AND CHICKS

  • Project Research
  • 1-5 Chapters
  • Abstract : Available
  • Table of Content: Available
  • Reference Style: APA
  • Recommended for : Student Researchers
  • NGN 3000

ABSTRACT

Ficus ingens (Miquel) Miquel belongs to the Moraceae family. In some African countries, extracts of the bark are administered to cows with a low milk production, and to people suffering from anaemia, piles and diarrhea. The behavior of living organisms is a visible manifestation of activity of the central nervous system, and mental and behavioural disorders pose a burden to the affected individual and the society at large, and anxiety disorders are inclusive occurring as the most common mental disorder. In this study, the behavioural effects of methanolic extract of Ficus ingens (Miquel) Miquel stem bark were investigated in mice at doses of 75, 150 and 300 mg/kg, using diazepam-induced sleeping time, hole board test, beam walking assay, elevated plus maze, elevated zero maze and staircase test in mice. The results revealed that the extract significantly (P<0.0005) prolonged the duration of diazepam-induced sleep without any effect on the latency to sleep at all the doses tested. The extract slightly decreased the number of head dips in the exploratory behaviour of mice in the hole board test; it also had a slight effect on the motor coordination of the mice in the beam walking assay. The extract showed anxiolysis in the staircase test characterized by significant (P<0.0005) decrease in the rearing behaviour. The extract had no significant effect on the number of open arm entries nor the time spent in the open arms as compared to the control group in both the plus maze and the zero maze. The methanolic extract of Ficus ingens (Miquel) Miquel stem bark was screened for anticonvulsant activity at doses of 125, 250, 500, 1000 and 2000 mg/kg intraperitoneally (i,p.) in mice and chicks against clonic seizures induced by Pentylenetetrazole (PTZ) (85 mg/kg, i.p.) and tonic seizures induced by Maximal electro shock (MES) (90 mA, 100Hz, 0.8sec) respectively. The extract at all doses 9 did not protect the mice from convulsion and mortality from PTZ except with 1000mg/kg dose that had a 100% protection against mortality. The extract at all doses had no effect on the mean recovery time of convulsed chicks. The oral and intraperitoneal LD50 were both found to be greater than 5000 mg/kg. These results suggest that the extract contains biologically active principles that have sedative as well as possible anxiolytic properties. The preliminary phytochemical screening revealed the presence of saponins, triterpenoids, alkaloids, flavonoids, phlobatanins and anthraquinones.




FIND OTHER RELATED TOPICS


Related Project Materials

INVESTIGATION ON THE FUNCTIONS OF YOUTH IN NATION DEVELOPMENT A CASE STUDY OF NIGERIA

Introduction

According to Johnson (2022), a person's role is the method in which they fulfill the responsibilities o...

Read more
BILINGUAL UNDERGRADUATES' USE OF ELECTRONIC MESSAGING: A LINGUISTIC AND ANTHROPOLOGICAL INVESTIGATION

INTRODUCTION AND BACKGROUND TO THE STUDY

 Around the world, practically every facet of human exist...

Read more
THE EFFECTS OF DIFFERENT SEATING ARRANGEMENTS IN HIGHER EDUCATION COMPUTER LAB CLASSROOMS ON STUDENT LEARNING, TEACHING STYLE, AND CLASSROOM APPRAISAL  

ABSTRACT

This study investigated the physical arrangement of workstations, seating and equipment in computer lab cla...

Read more
THE IMPACT OF MANAGEMENT STYLE ON THE EFFICIENCY OF SELECTED GOVERNMEMT OWNED COMPANIES

ABSTRACT

The research titled “The Impact of Management Style on the Efficiency of Selected Government Owned Companies In Enugu Stat...

Read more
IMPACT OF INDUSTRIAL CONFLICT MANAGEMENT ON EMPLOYEES PERFORMANCE

BACKGROUND TO THE STUDY

Industrial conflicts in organizations are inevitable. For employees to perform...

Read more
CRIME AND VIOLENCE AS A BARRIER TO GENDER EQUALITY IN NIGERIA

ABSTRACT

Women participation in Nigerian politics is crucial to the development of Nigeria and since wo...

Read more
FINANCIAL REPORTING QUALITY AND FIRM PERFORMANCE

Abstract:

This research explores the relationship between financial reporting quality and firm performa...

Read more
THE INFLUENCES OF OCCUPATIONAL SAFETY MANAGEMENT ON EMPLOYEE’S JOB COMMITMENT

ABSTRACT

Organization safety management is a function that hinges on the human resource department of every organization...

Read more
AN EXAMINATION OF THE ACCESSIBILITY, USE, MISUSE, AND EFFECTS OF COMBINED ORAL CONTRACEPTIVES AMONG WOMEN OF CHILD BEARING AGE

BACKGROUND TO THE STUDY

Family planning and contraception are among the major topics being debated thro...

Read more
IMPACT OF WORKFORCE DIVERSITY ON ORGANIZATIONAL PERFORMANCE IN CALABAR, CROSS-RIVER STATE

ABSTRACT

It is generally perceived that there is diversity in the workforce of any endeavor, be it business, government, or common societ...

Read more
Share this page with your friends




whatsapp